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DEPARTMENT OF BIOTECHNOLOGY
All India Institute of Medical Sciences (AIIMS),
Ansari Nagar, New Delhi-110029, India


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Dr. Vikram Saini


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Primary Affiliation:

Additional Professor,
Department of Biotechnology,
All India Institute of Medical Sciences,
Ansari Nagar,
New Delhi-110029


Secondary Affiliation:

Biosafety Level-3 Laboratory (BSL-3),
Centralized Core Research Facility (CCRF),
All India Institute of Medical Sciences,
Ansari Nagar, New Delhi-110029
Link to CCRF


Email ID: vikram@aiims.edu


Phone(O): +91-11-26594994


Google Scholar Link :- https://scholar.google.com/citations?user=zE4kGlwAAAAJ&hl=en


Lab Website: Dr. Vikram Saini


Profile:
Dr. Vikram Saini is an Additional Professor in the Department of Biotechnology at AIIMS New Delhi. He received his Ph.D. in Biochemistry from the University of Delhi South Campus and subsequently trained at the University of Alabama at Birmingham (USA), where he also served on the faculty before joining AIIMS. His research focuses on infection biology, immunometabolism, redox regulation, and translational approaches to infectious diseases, with work spanning tuberculosis, sepsis, fungal infections, and host-directed therapies. He is the recipient of several competitive awards, including Senior Research Fellowship from American Lung Association, HarGobind Khorana Innovative Young Biotechnologist Award (IYBA), DBT, Govt of India, AIIMS Innovative product development award, and very recently K. L. Wig Researcher of the year award (AIIMS New Delhi), one of the institute’s highest recognitions for research excellence and impact. Dr. Saini currently leads multiple nationally funded research programs supported by agencies such as DBT, ICMR, DRDO, and NCDC, and contributes to national initiatives in Translational Science, Biosafety and One Health. He is actively engaged in mentoring students and fostering a research environment that emphasizes scientific rigor, originality, and translational impact.


Research Interests:
Metabolism and bioenergetics of Infectious diseases, Redox Biology, Mycobacterial infections including HIV-TB co-infections, Nutrition and Virulence, Genomics and pathogenomics, Gaseous signaling and environmental risk factors for infections, Drug discovery and mechanisms of drug resistance.


Select Publications: (*Corresponding Author)

  1. Arya K, Negi S, Kumar A, Thakur K, Mehra S, Kumar A, Kumar R, Mehta S, Kataria R* and Saini V* (2025). Selective and sensitive detection of Nitric Oxide in aqueous and biological settings using a novel fluorescent Cobalt-MOF. Journal of Material Chemistry C 2025, 13, 11128-11143. https://doi.org/10.1039/D4TC04984E.

  2. *Saini V, Kalra P, Sharma M, Rai C, Saini Vikas, Gautam K, Bhattacharya S, Mani S, Saini K, Kumar S (2021). A cold chain independent specimen collection and transport medium improves diagnostic sensitivity, and minimizes biosafety challenges Covid19 molecular diagnosis. Microbiology Spectrum. 9, e01108-21 (2021) Doi: 10.1128/Spectrum.01108-21 $Patent filed. Research Highlight in Nature India: Microbial transport medium improves COVID-19 diagnostic. https://www.nature.com/articles/d44151-022-00003-x
    PMID: 34878310

  3. Kumar P, Saini K, *Saini V, *Mitchell T (2021). Oxalate Suppresses macrophage immunometabolism and anti-bacterial response to uropathogenic E. coli (UPEC) infection. Frontiers in Immunology. Vol 12, Article 694865. https://doi.org/10.3389/fimmu.2021.694865.
    PMID: 34745086

  4. Saini, V, Chinta, K.C., Reddy, V.P. et al. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nature Communications.(2020) doi:10.1038/s41467-019-14132-y
    This noxious gas aggravates TB
    PMID: 31992699

  5. Chinta K, Rahman A, Saini V, Glasgow J, Reddy VP et al. (2019) Microanatomic distribution of myeloid Heme Oxygenase-1 protects against free radical-mediated immunopathology in human tuberculosis. Cell Reports, 25 (7), 1938-1952. e5. (Cover page article).
    PMID: 30428359

  6. Gupta P, Kaur N, Saini V, Bala M, Sherawat S, Gupta S, Dua A, Kumar V, Dutt V, Injeti Elisha, Mittal A. (2019) Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems. Journal of Cellular Physiology, 234 (5), 6194-6208.
    PMID: 30317570

  7. Patel M, Yarlagadda V, Adedoyin O, Saini V, Oreoluwa D, Holmes R, Mitchell T. (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biology. Vol. 15, 207-215.
    PMID: 29272854

  8. Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, Grewal A, Gupta S, Dua A, Mittal A (2018). S-allyl cysteine inhibits TNF alpha induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochim Biophys Acta. (Gen Subjects); Vol. 1862 (4): 895-906.
    PMID: 29288771

  9. Saini V,Cumming BM, Guidry L, Lamprecht D, Adamson JH, Reddy VP, Chinta KC, Mazorodze J, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC (2016). Ergothioneine maintains redox and bioenergetichomeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis. Cell Reports. Vol.14, 1-14.
    PMID: 26774486

  10. Saini V, Raghuvanshi S, Ahmed N, Khurana JP, Hasnain SE, Tyagi Akhilesh K, Tyagi Anil K (2012). Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution.Nucleic Acids Res. doi: 10.1093/nar/gks793.Vol. 40 (21) 10832-10850.
    PMID: 22965120

    This is the first new bacterial species completely sequenced in India. Selected as a breakthrough article by NAR editorial board representing the top 5% of studies in terms of originality, significance and scientific excellence.

    Commentary at Nature: 'Mosaic genome' holds clue to TB, leprosy vaccines
    http://www.nature.com/nindia/2012/120921/full/nindia.2012.137.html

  11. Saini V, Farhana A, Glasgow JN, Steyn AJC (2012). Iron sulfur cluster proteins and microbial regulation: Implications for understanding tuberculosis.
    Current Opinion in Chemical Biology. Vol. 16 (1-2), 45-53.
    PMID: 22483328


I would be happy to discuss and sponsor self-motivated, hard-working and bright candidates applying for Post-doctoral fellowships/scientist positions for various funding agencies like DBT/DST and ICMR. Interested candidates should contact by email along with a 1-page write-up, CV and 3 references.





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